Androgenetic alopecia (male and lady pattern balding) is by far the most common cause of hair loss amongst men and a serious problem for various women. There are three vital components which are responsible for both woman and male balding:
1. A genetic predisposition for balding to occur.
2. Excessive presence of male hormones.
3. Aging – sufficient period for the first two factors to occur.
Both men and women produce male hormones that have a helpful role to play inside equally sexes; but the detail that androgens occur in much higher concentrations inside men explains why male pattern baldness is more familiar than the woman balding.
DHT the root cause of hair loss
It is metabolism of male hormones (androgen/testosterone) which is essential cause of hair loss and male and female pattern balding equally in men and women.
The metabolism of androgen involves an enzyme called 5 alpha reductase which combines using the hormone (testosterone) and converts it to DHT (Dihydro-testosterone). DHT is a expected metabolite of our body.
The cause of male and woman pattern balding
A few individuals, both men and women, are genetically pre-disposed to produce extra DHT than the expected individuals. It is this accumulation of DHT and its effect on the cells inside the hair follicle and root which is one of the primary causes of male and female pattern balding.
When DHT gets into the hair follicle and root, especially a region called the dermal papilla, it changes the cell’ activity and prevents requisite proteins, vitamins and minerals from providing nourishment desired to sustain life in the hairs of those follicles. Consequently, hair follicles are reproduced at a much slower rate. This shortens their growing stage (anagen phase) and or lengthens their resting stage (telogen phase) of the follicle. DHT also causes hair follicle to shrink and acquire progressively smaller and finer. This process is known since miniaturization and causes the hair to ultimately fall. DHT induced androgenetic aloepcia is responsible for 95% of each hair loss.
Blocking the synthesis of DHT at the molecular level forms the basis for the treat of MPHL (male pattern hair loss) and FPHL (female pattern hair loss). There are numerous accepted DHT blockers and a number of drugs which are used for medical hair restoration.
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